by Todd Smith

Linear chromosomes are hard to maintain.

Replication fork - .

Every time their DNA gets replicated, it gets shorter. This is due to the fact that DNA polymerase can only add bases to the terminal 3'-OH of a DNA chain. The DNA replication initiation complex uses RNA primers to provide the initial 3'-OH and to initiate "lagging" strand synthesis. While one strand can be copied all the way to the ... Read more

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